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Letters to the Editor
May 2002

Pharmacotherapy of Paraphilias With Luteinizing Hormone–Releasing Hormone Agonists

Arch Gen Psychiatry. 2002;59(5):469-470. doi:

In the November 2000 issue of the ARCHIVES, Meston and Frohlich1 provided a review of the past and current literature on the neurobiology of sexual function. We would like to add some facts about luteinizing hormone–releasing hormone (LH-RH) agonists. Experiences with LH-RH agonists have suggested that they might also be helpful in the treatment of paraphilias, especially in connection with sexual offending. Luteinizing hormone–releasing hormone agonists inhibit the production of testosterone by overwhelming the pulsatile stimulation of the pituitary gland by constant stimulation.

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