Copyright 2002 American Medical Association. All Rights Reserved.
Applicable FARS/DFARS Restrictions Apply to Government Use.2002
Drs Briken, Nika, and Berner add an important point to the discussion
of the neurobiology of sexual function. The Meston and Frohlich1
article discussed sexual drive from the perspective of normal sexual drive,
inhibited sexual drive, and treatments designed to increase sexual drive.
The main conclusion was that testosterone is not associated with sexual drive
in males unless testosterone levels falls below a critical level, as often
seen with hypogonadal men. A review of medications known to reduce sexual
drive and their mechanism of action certainly adds to this discussion. Indeed,
it is well established that luteinizing hormone–releasing hormone (LH-RH)
agonists reduce sexual drive, as noted by their effects on men taking them
as treatment for benign prostatic hyperplasia.2
Meston CM, Frohlich PF. Pharmacotherapy of Paraphilias With Luteinizing Hormone-Releasing Hormone Agonists. Arch Gen Psychiatry. 2002;59(5):470. doi:
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