Rhythmicity in the Regulation of Luteinizing Hormone Release

In the December 2000 issue of the ARCHIVES, Young et al¹ published an excellent article on alterations of the hypothalamic-pituitary-ovarian axis in depressed women, with a follow-up commentary by Halbreich.² In their article, Young and colleagues described decreased levels of circulating estradiol in the follicular phase of women with depression. They also report normal frequency and amplitude of the pulsatile release of luteinizing hormone (LH).