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Letters to the Editor
June 2002

Response Differences of Spontaneous Panic and Fear

Arch Gen Psychiatry. 2002;59(6):567-569. doi:

Gorman et al1 claim "evidence for a central fear mechanism" in panic disorder (PD). They state the following in their abstract:

Background: Inhalation of carbon dioxide (CO2) has been shown to produce more anxiety in patients with panic disorder (PD) than in healthy comparison subjects or patients with most other psychiatric illnesses tested, although premenstrual dysphoric disorder (PMDD) may be an exception. Several reasons have been proposed to explain CO2 breathing effects in PD. We examined differences in respiratory response to CO2 breathing in 4 groups to address these issues.