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Special Article
November 2002

The Interplay of Nature, Nurture, and Developmental Influences: The Challenge Ahead for Mental Health

Author Affiliations

From the Institute of Psychiatry, Kings College, London, England.

Arch Gen Psychiatry. 2002;59(11):996-1000. doi:10.1001/archpsyc.59.11.996

This article succinctly reviews research achievements in the fields of psychiatric genetics, psychosocial influences on mental disorder, and developmental processes. The challenges for the future are discussed in relation to finding and understanding the following: (1) susceptibility genes; (2) environmentally mediated causal risk processes; (3) nature-nurture interplay; (4) the effects of psychosocial adversity on the organism; (5) the causal processes responsible for group differences in rates of disorder; and (6) age-related changes in psychopathological characteristics.