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March 2006

Suicidal Risk in Antidepressant Drug Trials

Arch Gen Psychiatry. 2006;63(3):246-248. doi:10.1001/archpsyc.63.3.246

Suicide is the third leading cause of death in the United States at ages 10 through 24 years.1 Major depressive disorder and depressive phases of bipolar I and II disorders are associated with most suicides. Among patients with these disorders, suicide rates are 20-times or more higher than the international general population rate of about 0.015% per year.2,3 In addition, a lower ratio of attempted-to-completed suicide (approximately 5:1) than in the general population (approximately 25:1) suggests greater lethality of intent or methods of attempts among patients with mood disorder.2,4,5

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