Anti-inflammatory Intervention in Depression

To the Editor We acknowledge the important work published by Köhler et al.¹ This meta-analysis explored the clinical antidepressant effects of anti-inflammatories. The article found 14 randomized clinical trials and noted anti-inflammatory treatments (nonsteroidal anti-inflammatory drugs and cytokine inhibitors) reduce depressive symptoms vs placebo. The authors stated that the findings provide a proof of concept concerning anti-inflammatory treatments in depression; however, a high risk for bias and heterogeneity was noted.