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Comment & Response
May 2015

Anti-inflammatory Intervention in Depression—Reply

Author Affiliations
  • 1Research Department P, Aarhus University Hospital, Risskov, Denmark
  • 2The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark
  • 3Mental Health Centre Copenhagen, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
JAMA Psychiatry. 2015;72(5):512-513. doi:10.1001/jamapsychiatry.2014.3186

In Reply We read with interest the letters to the editor concerning our study,1 extending this important debate. The aim of our study was to review all randomized placebo-controlled clinical trials on the effect of anti-inflammatory intervention on depression, depressive symptoms, and adverse effects. The systematic review identified 14 trials, including 6262 patients, and the meta-analysis associated anti-inflammatory treatment with significant antidepressant treatment effect. Nonsteroidal anti-inflammatory drugs (NSAIDs), in particular the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib, showed adjunctive antidepressant effects, whereas results on cytokine inhibitors did not alone reach significance. Thus, the clinical potential of the conducted trials and their results support a proof of concept of anti-inflammatory intervention in depression.

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