Abuse-Deterrent Formulations of Prescription Opioids

To the Editor It is with interest that we read the article “Abuse-Deterrent Formulations and the Prescription Opioid Abuse Epidemic in the United States: Lessons Learned From OxyContin” published in JAMA Psychiatry.¹ Through their survey study, Cicero and Ellis¹ concluded that abuse-deterrent formulations (ADFs) can have the intended purpose of curtailing abuse, but only with limited effectiveness, and efforts to reduce opioid supply alone with ADF technology will not mitigate the opioid abuse program in the United States.