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Neuroscience and Psychiatry
September 2015

Neurodevelopmental Trajectories, Disconnection, and Schizophrenia Risk

Author Affiliations
  • 1Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
  • 2The Rotman Research Institute, Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, Canada
  • 3Child Mind Institute, New York, New York
JAMA Psychiatry. 2015;72(9):943-945. doi:10.1001/jamapsychiatry.2015.1119

In the last century, the following 2 concepts have guided our thinking about schizophrenia: schizophrenia as a neurodevelopmental disorder and disconnection syndrome. Although past examinations of developmental trajectories as premorbid antecedents have focused on gray matter, altered properties of white matter and connectivity have been gaining more attention in the pathophysiology of schizophrenia. Several studies, including a JAMA Psychiatry article,1 are beginning to illuminate the nature, timing, and clinical consequences of alterations in such developmental trajectories. Thus, the 2 concepts are coming together.

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