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February 2016

Prospective Community Studies Linking Cognitive Deficits to Subclinical Symptoms and a Step Toward Precision Medicine

Author Affiliations
  • 1Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia
JAMA Psychiatry. 2016;73(2):109-110. doi:10.1001/jamapsychiatry.2015.2621

The study by Mollon et al1 in this issue of JAMA Psychiatry exemplifies how the methodological rigor of a prospective community sample and validated tools combined with sophistication in data analysis result in theoretical insights with immediate and compelling implications for detection and treatment of psychiatric morbidity. The study has ramifications for psychiatry beyond its specific contribution to elucidating the profile of neurocognitive deficits associated with the experience of psychotic symptoms. The study also raises questions with which the field will need to grapple.

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