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March 2016

The Schizophrenia Polygenic Risk Score: To What Does It Predispose in Adolescence?

Author Affiliations
  • 1Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond
  • 2Department of Psychiatry, Virginia Commonwealth University, Richmond
  • 3Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond
JAMA Psychiatry. 2016;73(3):193-194. doi:10.1001/jamapsychiatry.2015.2964

The initial goal of genome-wide association studies (GWASs) of psychiatric disorders was to identify individual genetic variants that predispose to illness. Along the way, another application of GWAS data was discovered1: the polygenic risk score (PRS). The concept is simple. We start with all single-nucleotide polymorphisms (SNPs) assessed in a training sample. In this issue of JAMA Psychiatry, Jones et al2 report findings using the second Psychiatric Genomics Consortium schizophrenia GWAS as that sample.3