The initial goal of genome-wide association studies (GWASs) of psychiatric disorders was to identify individual genetic variants that predispose to illness. Along the way, another application of GWAS data was discovered1: the polygenic risk score (PRS). The concept is simple. We start with all single-nucleotide polymorphisms (SNPs) assessed in a training sample. In this issue of JAMA Psychiatry, Jones et al2 report findings using the second Psychiatric Genomics Consortium schizophrenia GWAS as that sample.3
Kendler KS. The Schizophrenia Polygenic Risk Score: To What Does It Predispose in Adolescence? JAMA Psychiatry. 2016;73(3):193–194. doi:10.1001/jamapsychiatry.2015.2964
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