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June 2016

Mindfulness-Based Cognitive Therapy and the Prevention of Depressive Relapse: Measures, Mechanisms, and Mediators

Author Affiliations
  • 1Center for Healthy Minds, and Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin–Madison
JAMA Psychiatry. 2016;73(6):547-548. doi:10.1001/jamapsychiatry.2016.0135

Mindfulness-based approaches to clinical interventions are receiving increasing attention in psychiatric research.1 The article in this issue of JAMA Psychiatry by Kuyken et al2 is an important meta-analysis of mindfulness-based cognitive therapy (MBCT) in the prevention of depression relapse. This meta-analysis was conducted at the individual patient level and included 9 randomized clinical trials, with data available for 1258 patients who participated in studies in which MBCT was compared with at least 1 non-MBCT treatment. The findings indicate that MBCT produced a reduced risk of depressive relapse within a 60-week follow-up period compared with other active treatments. Mindfulness-based cognitive therapy was most effective for patients with greater depressive severity before treatment.