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Comment & Response
October 2016

Use of Clozapine in Schizophrenia—Reply

Author Affiliations
  • 1Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany
JAMA Psychiatry. 2016;73(10):1098-1099. doi:10.1001/jamapsychiatry.2016.1331

In Reply We disagree with the comment by Mustafa that meta-analysis as a method is the reason for the unexpected results in our article.1 Meta-analysis is just reflecting the results of the included studies. Our meta-analysis confirmed that clozapine is better than first-generation antipsychotics. The unexpected finding that it is not better than second-generation antipsychotics would come exactly the same from a narrative reviewer of these trials as well; the blinded randomized evidence supporting the superiority of clozapine compared with other second-generation antipsychotics is currently insufficient.