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Comment & Response
October 2016

Hyperthermia for Major Depressive Disorder?—Reply

Author Affiliations
  • 1Department of Human Development and Family Studies, School of Human Ecology, University of Wisconsin–Madison
  • 2Department of Psychiatry, School of Medicine and Public Health, University of Wisconsin–Madison
  • 3Department of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder
JAMA Psychiatry. 2016;73(10):1096-1097. doi:10.1001/jamapsychiatry.2016.1917

In Reply We appreciate the insightful observations and questions raised by the letters from Fink and Shorter and Berk et al regarding our article.1 Here, we respond to each letter in turn.

Fink and Shorter query whether whole-body hyperthermia (WBH) might have appreciable efficacy for major depressive disorder (MDD) with melancholic features. To enter our randomized trial of WBH, participants had to meet DSM-IV-TR–defined MDD and to have a 17-item Hamilton Depression Rating Scale score of 16or greater. Thus, we did not select for individuals with melancholia as defined by the DSM. Here, we provide 2 somewhat conflicting observations.

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