Psychiatric symptoms do not co-occur randomly; some are more likely to covary than others. What accounts for such syndromic clustering?1 One explanation holds that an underlying categorical disease entity is the common cause of the emergence and covariance of the symptoms that reflect its presence. Hence, major depression can be the common cause of anhedonia, insomnia, and fatigue just as a malignant lung tumor can cause bloody sputum, dyspnea, and chronic cough.2
McNally RJ. Networks and Nosology in Posttraumatic Stress Disorder . JAMA Psychiatry. 2017;74(2):124–125. doi:10.1001/jamapsychiatry.2016.3344
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