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Invited Commentary
March 2017

The Need for Research on Treatments of Chronic Depression

Author Affiliations
  • 1Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
  • 2Department of Psychology, University of Pennsylvania, Philadelphia
  • 3Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine, School of Public Health, Kyoto, Japan
JAMA Psychiatry. 2017;74(3):242-243. doi:10.1001/jamapsychiatry.2016.4070

Chronic depression is one of the most challenging types of the major depressive disorders to treat, as many patients with chronic depression are resistant to several treatments, leaving clinicians with no or few treatment options available. From a public health perspective, chronic depressive disorders are also problematic because they are responsible for a considerable part of the disease burden of depression. The development of effective treatments for chronic depression is therefore one of the most important challenges for clinical research in depression.

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