Increasing the Use of Lithium and Clozapine in US Suicide Prevention

To the Editor The rising US suicide rate since 1999 is a significant public health issue, being the tenth leading cause of death overall. In JAMA Psychiatry, Hogan¹ highlighted that much can be done to reduce the US suicide rate but did not mention the potential role of lithium and clozapine for directly treating suicidality. The importance of these biologic interventions is often underestimated in suicide prevention strategies.²