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Invited Commentary
June 2017

A Brain Network–Based Grading of Psychosis: Could Resting Functional Magnetic Resonance Imaging Become a Clinical Tool?

Author Affiliations
  • 1Robarts Research Institute & The Brain and Mind Institute, University of Western Ontario, London, Ontario, Canada
  • 2Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
  • 3Lawson Health Research Institute, London, Ontario, Canada
  • 4Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China
  • 5School of Life Sciences, Fudan University, Shanghai, China
  • 6State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China
JAMA Psychiatry. 2017;74(6):613-614. doi:10.1001/jamapsychiatry.2017.0668

Cognitive deficits are the major contributing factors to social and vocational deficits across many major mental illnesses such as schizophrenia, bipolar disorder, and depression. Sheffield et al1 build on their previous investigations on the physiology of cognitive performance in psychosis to elegantly show that the generalized cognitive deficit in psychosis may result from a transdiagnostic, rather than a disorder-specific, impairment in the operation of large-scale brain networks. This is promising work that has enriched the translational potential of functional magnetic resonance imaging (fMRI) in treating psychosis.

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