Cognitive deficits are the major contributing factors to social and vocational deficits across many major mental illnesses such as schizophrenia, bipolar disorder, and depression. Sheffield et al1 build on their previous investigations on the physiology of cognitive performance in psychosis to elegantly show that the generalized cognitive deficit in psychosis may result from a transdiagnostic, rather than a disorder-specific, impairment in the operation of large-scale brain networks. This is promising work that has enriched the translational potential of functional magnetic resonance imaging (fMRI) in treating psychosis.
Palaniyappan L, Dempster K, Luo Q. A Brain Network–Based Grading of Psychosis: Could Resting Functional Magnetic Resonance Imaging Become a Clinical Tool? JAMA Psychiatry. 2017;74(6):613–614. doi:10.1001/jamapsychiatry.2017.0668
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