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Comment & Response
July 2017

First-Episode Schizophrenia and Diabetes Risk

Author Affiliations
  • 1Mental Health Institute of The Second Xiangya Hospital and Key Laboratory of Psychiatry and Mental Health of Hunan Province, The Central South University, Changsha, China
JAMA Psychiatry. 2017;74(7):762-763. doi:10.1001/jamapsychiatry.2017.0905

To the Editor In a recent meta-analysis in JAMA Psychiatry, Pillinger et al1 tackled a significant issue, that is, whether schizophrenia indicates an inherent risk for impaired glucose homeostasis. This study analyzed 16 studies, with 731 patients and 614 controls. Results showed that glucose homeostasis becomes impaired at the onset of schizophrenia, indicating that patients with schizophrenia are at increased risk for diabetes. The authors made an important contribution to this complex clinical problem; however, the conclusion might be a little premature.

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