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July 2017

Extending the Benefits of Indicated Prevention to Improve Outcomes of First-Episode Psychosis

Author Affiliations
  • 1Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom
  • 2OASIS Service, South London and the Maudsley National Health Service Foundation Trust, London, United Kingdom
JAMA Psychiatry. 2017;74(7):667-668. doi:10.1001/jamapsychiatry.2017.1009

Outcomes of psychotic disorders are associated with high personal, familiar, societal, and clinical burden. Thus, there is an urgent clinical and societal need for improving outcomes of psychosis. Research findings from the past 2 decades have opened new opportunities for ameliorating outcomes of psychosis through indicated primary prevention in individuals at clinical high risk for psychosis (CHR-P). Indicated primary prevention in individuals at CHR-P can result in (1) delayed or prevented onset of first episode. Furthermore, secondary prevention in individuals at CHR-P who will later develop the disorder may also (2) reduce the duration of untreated psychosis, hospital admission, and compulsory admission1 and (3) improve early detection and ameliorate the severity of first-episode cases.1

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