To the Editor To our knowledge, functional magnetic resonance imaging (fMRI) studies to date have reported both striatal hypoactivations and hyperactivations during anticipation and outcome notification of monetary rewards, making it impossible to fit the results to one specific theory of addiction. To clarify these contradicting findings, Luijten et al1 used meta-analyses of fMRI data to provide a valuable summary of results across many studies in the field of reward processing in addiction. We acclaim this study and would like to contribute to the discussion about the implications of the findings by pointing out some of the issues that need to be addressed in future research to further advance the field.
van Holst RJ, van Timmeren T, Goudriaan AE. Are There Differences in Disruptions of Reward Processing Between Substance Use Disorder and Gambling Disorder? JAMA Psychiatry. 2017;74(7):759–760. doi:10.1001/jamapsychiatry.2017.1051
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