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Neuroscience and Psychiatry
November 2017

Corollary Discharge, Self-agency, and the Neurodevelopment of the Psychotic Mind

Author Affiliations
  • 1Department of Mental Health, Reggio Emilia, Italy
  • 2Cmed Polyspecialistic Diagnostic and Therapeutic Centre, Rome, Italy
  • 3Childhood and Development Research Group, Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway
JAMA Psychiatry. 2017;74(11):1169-1170. doi:10.1001/jamapsychiatry.2017.2824

Corollary discharge (CD) impairment has been hypothesized to be a neurophysiological mechanism involved in the development of specific psychotic symptoms.1 Corollary discharge signals are copies of motor commands used to form a prediction of the sensation from self-generated movements, thereby contributing to the sense of self-agency. In more concrete terms, individuals have a subjective experience of volitionally controlling their own acts when the predicted sensation matches the actual sensation.

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