Can a brief psychosocial intervention (ie, Treatment Initiation and Participation Program) targeting medication barriers improve antidepressant adherence among middle-aged and older adults with a newly initiated depression treatment by primary care physicians?
In this randomized clinical trial, the Treatment Initiation and Participation Program participants were 3 times more likely to be at least 80% adherent to their antidepressant pharmacotherapy at both 6 and 12 weeks. The Treatment Initiation and Participation Program did not have a sustained effect on depression; however, participants who reported 80% adherence at both 6 and 12 weeks showed greater improvement in depression severity by 24 weeks.
The Treatment Initiation and Participation Program improved early adherence at weeks 6 and 12 combined and participants showed an early reduction in depressive symptoms at 6 weeks; participants in the Treatment Initiation and Participation Program and treatment as usual groups who were adherent at weeks 6 and 12 had a greater improvement in depressive symptoms.
Nonadherence to antidepressant medication is common and leads to poor outcomes. Early nonadherence is especially problematic.
To test the effectiveness of a psychosocial intervention to improve early adherence among older patients whose primary care physician newly initiated an antidepressant for depression.
Design, Setting, and Participants
The Treatment Initiation and Participation Program (TIP) was offered in a 2-site randomized clinical effectiveness study between January 2011 and December 2014 at primary care practices in New York, New York, and Ann Arbor, Michigan. Analyses began in February 2016. All participants were middle-aged and older adults (aged ≥55 years) who received newly initiated depression treatment by their primary care physician and recruited within 10 days of their prescription. Analyses were intention-to-treat.
Participants were randomly assigned to the intervention (TIP) or treatment as usual. Participants in the TIP group identified and addressed barriers to adherence, including stigma, misconceptions, and fears about treatment, before developing a personalized adherence strategy. The Treatment Initiation and Participation Program was delivered in three 30-minute contacts scheduled during a 6-week period just after the antidepressant was prescribed.
Main Outcomes and Measures
The primary outcome was self-reported adherence on the Brief Medication Questionnaire, with adequate early adherence defined as taking 80% or more of the prescribed doses at 6 and 12 weeks. The secondary outcome was depression severity.
In total, 231 middle-aged and older adults (167 women [72.3%] and 64 men [27.7%]) without significant cognitive impairment were randomly assigned to the TIP intervention (n = 115) or treatment as usual (n = 116). Participants had a mean (SD) age of 67.3 (8.4) years. Participants in the TIP group were 5 times more likely to be adherent at 6 weeks (odds ratio, 5.54; 95% CI, 2.57 to 11.96; χ21 = 19.05; P < .001) and 3 times more likely to be adherent at both 6 and 12 weeks (odds ratio, 3.27; 95% CI, 1.73 to 6.17; χ21 = 13.34; P < .001). Participants in the TIP group showed a significant earlier reduction (24.9%) in depressive symptoms (95% CI, 13.9 to 35.9; t337 = 4.46; adjusted P < .001). In both groups, participants who were 80% adherent at weeks 6 and 12 had a 15% greater improvement in depressive symptoms from baseline over the course of treatment (95% CI, −0.2 to −30; t369 = 1.93; P = .051).
Conclusions and Relevance
The Treatment Initiation and Participation Program is an effective intervention to improve early adherence to pharmacotherapy. Improved adherence can promote improvement in depression.
clinicaltrials.gov Identifier: NCT01301859
Sirey JA, Banerjee S, Marino P, Bruce ML, Halkett A, Turnwald M, Chiang C, Liles B, Artis A, Blow F, Kales HC. Adherence to Depression Treatment in Primary CareA Randomized Clinical Trial. JAMA Psychiatry. Published online September 27, 2017. doi:10.1001/jamapsychiatry.2017.3047
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