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In This Issue of JAMA Psychiatry
October 2017

Highlights

JAMA Psychiatry. 2017;74(10):981. doi:10.1001/jamapsychiatry.2016.2541
Research

Binge eating disorder is the most common eating disorder worldwide, and cognitive behavioral therapy is the treatment of choice for this condition. Thus, it is important to know the efficacy of an internet-based delivery of this intervention, which would make it more readily available. de Zwaan and colleagues enrolled 178 adult individuals with binge eating problems in a prospective, multicenter, randomized, noninferiority clinical trial to examine the efficacy of face-to-face vs Internet-based cognitive behavioral therapy. Symptoms of binge eating improved faster and significantly more with face-to-face relative to internet-based cognitive behavioral therapy.

Lithium in therapeutic doses may improve memory and modify the risk of dementia. Kessing and colleagues used a Danish population-based register to study the effect of long-term exposure to lithium in drinking water on the incidence of dementia. Lithium exposure was significantly lower in patients with a diagnosis of dementia. In an Editorial, McGrath and Berk discuss the potential effect of this finding on dementia prevention strategies.

Editorial

Selective serotonin and serotonin-norepinephrine reuptake inhibitors are frequently used to treat mood and anxiety disorders in children and adolescents. Locher and colleagues present a meta-analysis of the efficacy and safety of these treatments. Selective serotonin and serotonin-norepinephrine reuptake inhibitors were significantly more effective than placebo in treating common pediatric psychiatric disorders but also led to significant adverse events. In an Editorial, Merry and colleagues comment on the implications of the findings for clinical practice.

Editorial

Continuing Medical Education

Preventive interventions have been developed to prevent the early and impairing consequences of childhood anxiety. Moreno-Peral and colleagues examined the efficacy of these interventions using a meta-analysis of 29 randomized clinical trials including 10 430 youths across 11 countries. Overall, the interventions were effective in preventing anxiety, with larger effect sizes associated with wait list as the comparator group and smaller sample size. In an Invited Commentary, Hudson comments on the findings and raises important questions for future directions.

Invited Commentary

Maternal antidepressant medication use during pregnancy has previously been associated with several adverse outcomes in offspring. Viktorin and colleagues studied the relative risks for intellectual disability. In a population-based cohort study of 179 007 pregnancies, an association of maternal antidepressant use with intellectual disability was attenuated when factors other than medication use were taken into account. The authors conclude that the elevated risk of intellectual disability is not owing to maternal antidepressant medication use during pregnancy but owing to factors such as parental age and psychiatric disorder.

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