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Comment & Response
April 2018

Mendelian Randomization Concerns—Reply

Author Affiliations
  • 1Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
  • 2Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, England
  • 3Population Health Sciences, University of Bristol, Bristol, England
JAMA Psychiatry. 2018;75(4):407-408. doi:10.1001/jamapsychiatry.2017.4725

In Reply The comments by Lin et al on our mendelian randomization analysis of the association of circulating C-reactive protein (CRP) with schizophrenia risk1 indicate their concern over the proper extraction and harmonization of data within 2-sample mendelian randomization studies. We agree that this is an important topic2 that is vital for ensuring the reproducibility and reliability of scientific findings, and we appreciate the opportunity to provide some clarifications.

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