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Invited Commentary
May 2018

An Interactive Developmental Neuroscience Perspective on Adolescent Resilience to Familial Depression

Author Affiliations
  • 1Department of Psychiatry, University of Illinois at Chicago, Chicago
JAMA Psychiatry. 2018;75(5):503-504. doi:10.1001/jamapsychiatry.2018.0050

Decades of empirical and theoretical work have been directed toward identifying risk factors in the intergenerational transmission of depression. Receiving considerably less attention in the field is the study of attributes that might constitute protection from major depressive disorder (MDD) among offspring of parents with depression. This disinterest persists despite research showing that roughly 40% of such offspring never go on to develop the disorder. Thus, resiliency to depression, whether a foundational trait or the outcome of several interactive factors across development, may reflect processes that can be identified, targeted, and enhanced in prevention and intervention efforts.