Safety of Estradiol Treatment in Perimenopausal Asymptomatic Women

To the Editor In their article, Gordon et al¹ assessed the efficacy of transdermal estradiol and micronized progesterone in the primary prevention of depressive symptoms during menopause transition. They concluded that 12 months of transdermal estradiol associated with intermittent micronized progesterone was more effective than placebo in preventing the development of clinically significant depressive symptoms among initially euthymic perimenopausal and early postmenopausal women.