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Neuroscience and Psychiatry
July 2018

Neuroprotective Effects of Prenatal Folic Acid Supplementation: Why Timing Matters

Author Affiliations
  • 1Department of Psychiatry, Massachusetts General Hospital, Charlestown
  • 2Harvard Medical School, Boston, Massachusetts
JAMA Psychiatry. 2018;75(7):747-748. doi:10.1001/jamapsychiatry.2018.0378

Neurodevelopmental theories of autism, schizophrenia, and other brain disorders implicate the fetal environment.1 Although certain toxic exposures during pregnancy (eg, infection, malnutrition, and urbanicity) have been repeatedly associated with disease risk, specific etiologic mechanisms remain unclear. However, alterations in the fetal methylation milieu are likely of central importance.