Neurodevelopmental theories of autism, schizophrenia, and other brain disorders implicate the fetal environment.1 Although certain toxic exposures during pregnancy (eg, infection, malnutrition, and urbanicity) have been repeatedly associated with disease risk, specific etiologic mechanisms remain unclear. However, alterations in the fetal methylation milieu are likely of central importance.
Roffman JL. Neuroprotective Effects of Prenatal Folic Acid Supplementation: Why Timing Matters. JAMA Psychiatry. 2018;75(7):747–748. doi:10.1001/jamapsychiatry.2018.0378
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