A wide variety of cohort studies, conducted primarily in Europe and North America, have reported that cognitive activity reduces the risk of dementia, Alzheimer disease, or cognitive decline.1,2 In this issue of JAMA Psychiatry, Lee et al3 report a similar finding in a different population: 15 582 older adult residents of Hong Kong who were dementia-free at baseline and followed up for a median of 5 years. The study is carefully done, with systematic evaluation of cognitive activity, careful baseline and follow-up cognitive assessments, collection of data on a wide variety of potential confounding factors, and efforts to limit loss to follow-up and missing data.
Blacker D, Weuve J. Brain Exercise and Brain Outcomes: Does Cognitive Activity Really Work to Maintain Your Brain? JAMA Psychiatry. 2018;75(7):703–704. doi:10.1001/jamapsychiatry.2018.0656
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