To the Editor The recent Viewpoint by Zubenko et al1 on pharmacogenetic tests for psychiatric treatment boldly states “the available evidence suggests Pgen [pharmacogenetic] tests will not contribute much to care.” However, we believe that the foundation from which the authors based their statement is incomplete and potentially misleading. Their statement has inadvertently assumed that (1) all pharmacogenetic testing is created equal with respect to their underlying scientific evidence and recommendations and (2) pharmacogenetic testing is incompatible with protocol-based care.