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Research Letter
November 2018

Targeting Withdrawal Symptoms in Men Addicted to Methamphetamine With Transcranial Magnetic Stimulation: A Randomized Clinical Trial

Author Affiliations
  • 1School of Social and Behavioral Sciences, Nanjing University, Nanjing, China
  • 2Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China
  • 3Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China
  • 4Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, China
  • 5School of Psychology, Nanjing Normal University, Nanjing, China
JAMA Psychiatry. 2018;75(11):1199-1201. doi:10.1001/jamapsychiatry.2018.2383

Drug withdrawal is associated with aversive experiences, which promotes relapse.1 Different neurotransmitters, neuropeptides, signal transduction pathways, and brain regions (especially the nucleus accumbens) have been implicated in the occurrence of withdrawal syndrome during abstinence from addictive drugs.2 Withdrawal from methamphetamine results in fatigue, irritability, disturbed sleep, exhaustion, and symptoms of depression and anxiety, which might last for months. Currently, limited pharmaceutical tools are available for detoxification from methamphetamine; vitamins, antidepressants, and antipsychotics have been used to ameliorate withdrawal symptoms in clinical practices.3