Drug withdrawal is associated with aversive experiences, which promotes relapse.1 Different neurotransmitters, neuropeptides, signal transduction pathways, and brain regions (especially the nucleus accumbens) have been implicated in the occurrence of withdrawal syndrome during abstinence from addictive drugs.2 Withdrawal from methamphetamine results in fatigue, irritability, disturbed sleep, exhaustion, and symptoms of depression and anxiety, which might last for months. Currently, limited pharmaceutical tools are available for detoxification from methamphetamine; vitamins, antidepressants, and antipsychotics have been used to ameliorate withdrawal symptoms in clinical practices.3
Liang Y, Wang L, Yuan T. Targeting Withdrawal Symptoms in Men Addicted to Methamphetamine With Transcranial Magnetic StimulationA Randomized Clinical Trial. JAMA Psychiatry. 2018;75(11):1199–1201. doi:10.1001/jamapsychiatry.2018.2383
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