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Comment & Response
October 10, 2018

Autoimmune Thyroiditis and Depression

Author Affiliations
  • 1Department of Psychiatry and Psychotherapy, University of Cologne Medical School, Cologne, Germany
JAMA Psychiatry. Published online October 10, 2018. doi:10.1001/jamapsychiatry.2018.2411

To the Editor Siegmann et al1 present high odds ratios (ORs) for the association of autoimmune thyroiditis (AIT) with depressive (OR, 3.56 [95% CI, 2.14-5.94]) and anxiety (OR, 2.32 [95% CI, 1.40-3.85]) disorders. Using National Comorbidity Survey Replication data, they conclude that annually, 24% of patients with AIT experience depression and 42% experience anxiety disorders. However, they have treated ORs as relative risks. Using their model and correcting for the difference between OR and relative risks, prevalences decrease to 20% for depression and 34% for anxiety disorders.