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Research Letter
December 12, 2018

Factors Associated With Successful Medication Discontinuation After a Randomized Clinical Trial of Relapse Prevention in First-Episode Psychosis: A 10-Year Follow-up

Author Affiliations
  • 1Department of Psychiatry, University of Hong Kong, Hong Kong
  • 2Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
  • 3Department of Psychiatry, University of Hong Kong, Hong Kong
  • 4State Key Laboratory of Brain and Cognitive Sciences, University of Hong Kong, Hong Kong
JAMA Psychiatry. Published online December 12, 2018. doi:10.1001/jamapsychiatry.2018.3120

Not all patients with psychotic disorders require a lifetime of antipsychotic treatment. A study of patients on the schizophrenia spectrum found that after a mean duration of illness of 10.4 years, 24 of 70 (34%) were free of antipsychotic medication for at least 3 months, of whom 20 were medication-free for longer than a year.1 Another study of first-episode psychosis reported that at 7-year follow-up, 17 of 103 patients (16.5%) had stopped antipsychotic medication during the previous 2 years.2 Identifying clinical features of illness associated with lesser or greater likelihood of successfully discontinuing antipsychotic medication is of considerable importance. We report the proportion and factors associated with successful discontinuation during long-term follow-up of patients with first-episode psychosis.