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December 26, 2018

Cognitive Impairment and Depression—Cause, Consequence, or Coincidence?

Author Affiliations
  • 1Institute of Cognitive Neuroscience, University College London, London, England, United Kingdom
  • 2Division of Psychiatry, University College London, London, England, United Kingdom
JAMA Psychiatry. 2019;76(3):239-240. doi:10.1001/jamapsychiatry.2018.3631

Depression is reliably associated with cognitive impairment, but the causal nature of this relationship remains unclear. This is important because if cognitive impairment drives the development of depressive symptoms, boosting cognition may help to treat or even prevent depression. In this issue of JAMA Psychiatry, MacKenzie and colleagues1 address this issue, performing a systematic review and meta-analysis of cognition in individuals with a first-degree relative with depression.