[Skip to Navigation]
Comment & Response
March 27, 2019

Notice of Retraction and Replacement: Ecker et al. Association between the probability of autism spectrum disorder and normative sex-related phenotypic diversity in brain structure. JAMA Psychiatry. 2017;74(4):329-338

Author Affiliations
  • 1Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Goethe University, Frankfurt am Main, Germany
JAMA Psychiatry. 2019;76(5):549-550. doi:10.1001/jamapsychiatry.2018.4296

To the Editor On behalf of my coauthors, I write to report serious errors that occurred in our article, “Association Between the Probability of Autism Spectrum Disorder and Normative Sex-Related Phenotypic Diversity in Brain Structure,” that was published online on February 8, 2017, and in the April 2017 issue of JAMA Psychiatry.1 In this article, we reported the results of a case-control study of 98 high-functioning adults with autism spectrum disorder (ASD) and a control group of 98 matched neurotypical adults. We examined the probability of ASD as a function of normative sex-related phenotypic diversity in brain structure in male and female individuals with ASD and the matched neurotypical controls using gaussian process classification. We concluded that the probability of ASD increased significantly from a characteristic female to male brain phenotype, particularly in female individuals with ASD, and that the neuroanatomical patterns carrying high and low risk of ASD overlapped with brain regions with significant sex-by-group interactions in brain structure.

Add or change institution