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Comment & Response
May 29, 2019

Exploring the Association of Sex Differences and Exposure to Maternal Smoking With Low Fetal Growth—Reply

Author Affiliations
  • 1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  • 2Department of Psychology, University of Indiana, Bloomington, Indiana
JAMA Psychiatry. 2019;76(7):767-768. doi:10.1001/jamapsychiatry.2019.1127

In Reply We thank Jha et al and Aubin et al for their interest in our Original Investigation.1 Jha and colleagues speculate that the association of low fetal growth with depression might be stronger among female individuals. To test this hypothesis, we stratified by sex and regressed depression onto the clinical diagnosis small for gestational age within sibling pairs. Although the results were not statistically significant, they are in the hypothesized direction (male probit: β = 0.009, SE = 0.044 and female probit: β = 0.067, SE = 0.035). While this is an interesting hypothesis, we remain agnostic about its veracity given that the difference is not statistically significant and that it is unclear if the association remains after partialling out what depression shares with all other disorders.

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