In this issue of JAMA Psychiatry, Periyasamy et al1 report that rs10866912, a single-nucleotide polymorphism, is associated with schizophrenia. In other words, when the investigators compared the frequency of alleles (variants) from a panel of single-nucleotide polymorphisms, the frequency of allele A of this biallelic genetic polymorphism was significantly higher among patients with schizophrenia than control participants, based on a genome-wide association study (GWAS). The authors1 thus contend that the A allele of rs10866912 is a risk factor for schizophrenia. The estimated risk is modest, with an odds ratio of 1.27, but it is significant after corrections for genome-wide multiple comparisons (P = 4.35 × 10−8).
Nimgaonkar VL, Wood J, Deshpande S. A Unique Genome-wide Association Study of a Psychiatric Disorder From India. JAMA Psychiatry. Published online July 03, 201976(10):1003–1004. doi:10.1001/jamapsychiatry.2019.1325
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