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July 3, 2019

A Unique Genome-wide Association Study of a Psychiatric Disorder From India

Author Affiliations
  • 1Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • 2Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania
  • 3Post Graduate Institute for Medical Education and Research, Dr Ram Manohar Lohia Hospital, New Delhi, India
JAMA Psychiatry. 2019;76(10):1003-1004. doi:10.1001/jamapsychiatry.2019.1325

In this issue of JAMA Psychiatry, Periyasamy et al1 report that rs10866912, a single-nucleotide polymorphism, is associated with schizophrenia. In other words, when the investigators compared the frequency of alleles (variants) from a panel of single-nucleotide polymorphisms, the frequency of allele A of this biallelic genetic polymorphism was significantly higher among patients with schizophrenia than control participants, based on a genome-wide association study (GWAS). The authors1 thus contend that the A allele of rs10866912 is a risk factor for schizophrenia. The estimated risk is modest, with an odds ratio of 1.27, but it is significant after corrections for genome-wide multiple comparisons (P = 4.35 × 10−8).