In Reply We read with great interest the letter by Neerland et al and fully agree with the opinions about delirium management that: (1) the most important actions are to identify and correct the underlying causes and apply symptomatic treatment of behavioral symptoms and distress and (2) there is a prioritization of multicomponent, nonpharmacological approaches for the prevention and treatment of delirium without any one-size-fits-all pharmacologic treatment. They also reemphasized our conclusion that the findings1 should not be generalized to routine clinical practice because the result of combination of haloperidol plus lorazepam was derived from only 1 randomized clinical trial (RCT) and the mean age of individuals in the current study was relatively young.
Tseng P, Su K. Pharmacological Management of Delirium—Reply. JAMA Psychiatry. Published online July 03, 201976(9):983–984. doi:10.1001/jamapsychiatry.2019.1522
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