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Comment & Response
July 3, 2019

Pharmacological Management of Delirium—Reply

Author Affiliations
  • 1WinShine Clinics in Specialty of Psychiatry, Kaohsiung City, Taiwan
  • 2Department of Psychiatry & Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung, Taiwan
  • 3College of Medicine, China Medical University, Taichung, Taiwan
JAMA Psychiatry. 2019;76(9):983-984. doi:10.1001/jamapsychiatry.2019.1522

In Reply We read with great interest the letter by Neerland et al and fully agree with the opinions about delirium management that: (1) the most important actions are to identify and correct the underlying causes and apply symptomatic treatment of behavioral symptoms and distress and (2) there is a prioritization of multicomponent, nonpharmacological approaches for the prevention and treatment of delirium without any one-size-fits-all pharmacologic treatment. They also reemphasized our conclusion that the findings1 should not be generalized to routine clinical practice because the result of combination of haloperidol plus lorazepam was derived from only 1 randomized clinical trial (RCT) and the mean age of individuals in the current study was relatively young.