Decades of research have implicated both genetic and environmental risk factors for autism spectrum disorder (ASD). However, only in recent years have population-based studies been able to place risk in a broader context, allowing the relative influence of these factors on ASD liability to be better estimated. In this issue of JAMA Psychiatry, Bai and coauthors1 report the findings of the most comprehensive family-based study to date.
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Jutla A, Reed H, Veenstra-VanderWeele J. The Architecture of Autism Spectrum Disorder Risk: What Do We Know, and Where Do We Go From Here? JAMA Psychiatry. 2019;76(10):1005–1006. doi:10.1001/jamapsychiatry.2019.1375
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