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July 31, 2019

Clozapine and Evidence-Based Psychopharmacology for Schizophrenia

Author Affiliations
  • 1Department of Psychiatry, Columbia University Irving Medical Center and New York State Psychiatric Institute, New York
JAMA Psychiatry. 2019;76(10):1007-1008. doi:10.1001/jamapsychiatry.2019.1656

On treatment of schizophrenia with medication, evidence-based guidelines agree on definitive recommendations for only a small number of issues: antipsychotic drugs should be used to reduce symptoms and the risk of relapse and rehospitalization, and clozapine is indicated for treatment-resistant schizophrenia and people with persistent suicidality or hostility.1,2 The guidelines also provide more granular recommendations on how and when to use antipsychotic drugs. The evidence and guidelines are murkier on other issues, such as the use of other types of psychotropic medications, combinations of antipsychotic agents, and the role of long-acting, injectable antipsychotic drugs.

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