[Skip to Navigation]
Views 732
Citations 0
Editor's Note
July 31, 2019

Challenges When Conducting Complex Clinical Research

Author Affiliations
  • 1McLean Hospital, Belmont, Massachusetts
  • 2Editor, JAMA Psychiatry
JAMA Psychiatry. 2019;76(10):1017. doi:10.1001/jamapsychiatry.2019.1657

In this issue of JAMA Psychiatry, Weiser and coauthors1 report the results of a randomized clinical trial on the salutary effects of adjunctive estradiol treatment on schizophrenia in women. This study extends the literature on an unusual hormone-based approach to ameliorating symptoms of psychosis. It was judged to be of scientific merit and clinical relevance by our editors and external peer reviewers. Concern was raised, however, when we were unable to access the trial registration for the trial on EudraCT (EudraCT No. 2014-005511-16) during editorial review. In response to our inquiry, the investigators identified the following issues.

Add or change institution
Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words