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Editor's Note
July 31, 2019

Challenges When Conducting Complex Clinical Research

Author Affiliations
  • 1McLean Hospital, Belmont, Massachusetts
  • 2Editor, JAMA Psychiatry
JAMA Psychiatry. 2019;76(10):1017. doi:10.1001/jamapsychiatry.2019.1657

In this issue of JAMA Psychiatry, Weiser and coauthors1 report the results of a randomized clinical trial on the salutary effects of adjunctive estradiol treatment on schizophrenia in women. This study extends the literature on an unusual hormone-based approach to ameliorating symptoms of psychosis. It was judged to be of scientific merit and clinical relevance by our editors and external peer reviewers. Concern was raised, however, when we were unable to access the trial registration for the trial on EudraCT (EudraCT No. 2014-005511-16) during editorial review. In response to our inquiry, the investigators identified the following issues.

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