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Comment & Response
October 2, 2019

Concerns Regarding a Meta-analysis Comparing Psychotherapy with Medications for Posttraumatic Stress Disorder—Reply

Author Affiliations
  • 1Division of Clinical Psychology and Psychotherapy, Faculty of Psychology, University of Basel, Basel, Switzerland
JAMA Psychiatry. Published online October 2, 2019. doi:10.1001/jamapsychiatry.2019.2927

In Reply The reactions from Stein and Norman,1 Sonis and Cook, and Zheng et al to our article2 reflect a large interest in the addressed topic and will hopefully motivate the conduct of high-quality studies in this context in the future. In 1981, recommendations were published on how to design a comparative study, which aims at comparing pharmacological and psychotherapeutic treatments.3 In our network meta-analysis, no single study adhered to these recommendations.2 Now, what is the value of a meta-analysis that includes mostly studies that did not adhere to high methodological standards?

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