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Comment & Response
November 6, 2019

Is Variance Ratio a Valid Indicator of Heterogeneous Treatment Effect?—Reply

Author Affiliations
  • 1University Hospital of Psychiatry Zurich, Zurich, Switzerland
  • 2Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, New York
  • 3Division of Psychiatry Research, Zucker Hillside Hospital, Northwell Health, New York, New York
  • 4Department of Psychiatry, Zucker School of Medicine at Northwell/Hofstra, Hempstead, New York
JAMA Psychiatry. 2020;77(2):217-218. doi:10.1001/jamapsychiatry.2019.3382

In Reply We welcome the discussion on our recent article1 on individual differences in response to antipsychotic treatment because we believe that the issues surrounding personalized medicine deserve more attention. We agree with Bae that the distinction between interactions of treatment by patient and treatment by subgroup is useful in elucidating what may cause variance differences between groups; it corresponds with the distinction between personalized medicine and stratified medicine.2

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