In Reply We welcome the discussion on our recent article1 on individual differences in response to antipsychotic treatment because we believe that the issues surrounding personalized medicine deserve more attention. We agree with Bae that the distinction between interactions of treatment by patient and treatment by subgroup is useful in elucidating what may cause variance differences between groups; it corresponds with the distinction between personalized medicine and stratified medicine.2
Identify all potential conflicts of interest that might be relevant to your comment.
Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.
Err on the side of full disclosure.
If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.
Not all submitted comments are published. Please see our commenting policy for details.
Winkelbeiner S, Homan P. Is Variance Ratio a Valid Indicator of Heterogeneous Treatment Effect?—Reply. JAMA Psychiatry. 2020;77(2):217–218. doi:10.1001/jamapsychiatry.2019.3382
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.