In Reply We welcome the discussion on our recent article1 on individual differences in response to antipsychotic treatment because we believe that the issues surrounding personalized medicine deserve more attention. We agree with Bae that the distinction between interactions of treatment by patient and treatment by subgroup is useful in elucidating what may cause variance differences between groups; it corresponds with the distinction between personalized medicine and stratified medicine.2
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Winkelbeiner S, Homan P. Is Variance Ratio a Valid Indicator of Heterogeneous Treatment Effect?—Reply. JAMA Psychiatry. Published online November 06, 2019. doi:https://doi.org/10.1001/jamapsychiatry.2019.3382
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