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Editorial
December 4, 2019

Relapse Prevention After Recovery in Patients With Persistent Major Depressive Disorder—An Active Pursuit

Author Affiliations
  • 1Ammon-Pinizzotto Center for Women’s Mental Health, Clinical Trials Network and Institute, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
JAMA Psychiatry. 2020;77(3):231-232. doi:10.1001/jamapsychiatry.2019.3637

In this issue of JAMA Psychiatry, DeRubeis et al1 present the second phase of an elegantly designed study that has yielded results that will inform patient care and future research. A paucity of studies is available to inform the long-term treatment of persistent major depressive disorder (MDD), either chronic or recurrent.2 Most studies have focused on short-term treatment with single interventions, and many longer-term studies have not been controlled.

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