In this issue of JAMA Psychiatry, DeRubeis et al1 present the second phase of an elegantly designed study that has yielded results that will inform patient care and future research. A paucity of studies is available to inform the long-term treatment of persistent major depressive disorder (MDD), either chronic or recurrent.2 Most studies have focused on short-term treatment with single interventions, and many longer-term studies have not been controlled.
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Freeman MP. Relapse Prevention After Recovery in Patients With Persistent Major Depressive Disorder—An Active Pursuit. JAMA Psychiatry. 2020;77(3):231–232. doi:10.1001/jamapsychiatry.2019.3637
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