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Negative symptoms represent a substantial burden in schizophrenia without an available effective treatment. Valiengo and colleagues conducted a double-blind sham-controlled randomized clinical trial of add-on transcranial direct current stimulation for negative symptoms in 100 stable patients with schizophrenia and found that 10 sessions over the left prefrontal cortex over 5 days led to significantly greater improvement in negative symptom scores at weeks 6 and 12 when compared with the sham procedure. Thus, transcranial direct current stimulation is effective and safe in ameliorating negative symptoms in patients with schizophrenia.
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Stellate ganglion block treatment has been proposed but not adequately studied for treating posttraumatic stress disorder. Rae Olmsted and colleagues conducted a blinded sham-controlled randomized clinical trial with 113 active-duty service members with posttraumatic stress disorder symptoms and found that right-sided stellate ganglion block at weeks 0 and 2 was significantly more effective for reducing these symptoms from baseline to 8 weeks than sham procedure was. These findings indicate that stellate ganglion block merits further study as a posttraumatic stress disorder treatment.
Highlights. JAMA Psychiatry. 2020;77(2):109. doi:10.1001/jamapsychiatry.2019.2784
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