As physicians, we are concerned that the role of social connectedness in combating burnout among medical professionals is not receiving the emphasis that it deserves. While many interventions to reduce burnout have been proposed, none is more important, in our view, than addressing the fundamental human need to belong. In this Viewpoint, we emphasize that social connectedness is a basic human need that when lost leads to burnout, and we encourage health care institutions to apply lessons from team and organizational literature to increase social connectedness and enhance well-being.