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Comment & Response
April 22, 2020

Effect Size and Blinding in Lumateperone Trial

Author Affiliations
  • 1Department of Psychiatry, Boston University Medical Center, Boston, Massachusetts
  • 2Mental Health Service Line, Edith Nourse Rogers Memorial VA Medical Center, Bedford, Massachusetts
  • 3Departments of Psychiatry and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester
JAMA Psychiatry. 2020;77(6):650-651. doi:10.1001/jamapsychiatry.2020.0610

To the Editor The article “Efficacy and Safety of Lumateperone for Treatment of Schizophrenia: A Randomized Clinical Trial”1 by Correll and colleagues was notable for its thorough data analyses (including multiple sensitivity analyses of the primary outcome) and for the relatively low rate of both negative metabolic effects and extrapyramidal symptoms observed with lumateperone. These 2 classes of adverse events have been associated with treatment nonadherence in this vulnerable patient population.2

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