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July 1, 2020

Modified Positive and Negative Syndrome Scale—A Journey of a Thousand Miles Starts With the First Step

Author Affiliations
  • 1WCG MedAvante-ProPhase Inc, New York, New York
  • 2PANSS Institute, New York, New York
  • 3Shanghai Mental Health Center, Shanghai Jiaotong University Medical School, Shanghai, China
JAMA Psychiatry. Published online July 1, 2020. doi:10.1001/jamapsychiatry.2020.1288

The approach to the development of new psychiatric drugs is frequently criticized for being inefficient, slow, and plagued by dated methods and archaic outcome measures.1,2 For the US Food and Drug Administration (FDA), the rate of success for new drug candidates has decreased over the past decades, owing in part to increasing response to placebo and decreasing response to treatment.3 It may seem excessive to say, “the clinical trials system is broken,” but this statement is the verbatim title of at least 1 publication.4 Even the most ardent defenders of the status quo may admit that some things need to change.

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