You cannot be serious.John McEnroe, 19811
You cannot be serious.
In 2016, we published an article in the American Journal of Psychiatry,2 raising concerns about the interpretation of magnetic resonance imaging (MRI) acquired with pulse sequences designed to visualize brain structure. We opined that routine interpretation of data from such scans comparing patients with psychiatric diagnoses with control individuals was potentially confounded by many epiphenomena and artifacts that render conclusions about differences representing cerebral structure, ie, the basic cellular elements of the tissue, problematic if not unsubstantiated. We suggested that rather than referring to differences as evidence of brain structural abnormalities, they should be called differences on MRI measurements. Since that report, 24 studies (structural MRI and/or diffusion MRI) have appeared in JAMA Psychiatry and 22 in the American Journal of Psychiatry, describing differences in such scans in samples of psychiatric patients, and none of them have used this suggested phrase in interpretation of findings. All have concluded that the findings are evidence of potentially deleterious changes in brain structure.
Weinberger DR, Radulescu E. Structural Magnetic Resonance Imaging All Over Again. JAMA Psychiatry. 2021;78(1):11–12. doi:10.1001/jamapsychiatry.2020.1941
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